Jump to content
  • Recently Browsing   0 members

    No registered users viewing this page.

EDDIEKIRK

Alzheimer’s Caused By Loss of Cannabinoids,

Rate this topic

Recommended Posts

Early deficits in Alzheimer’s may be caused by blockage of the brain’s cannabinoids, according to new research out of Stanford University.

http://med.stanford.edu/news/all-news/2014/06/blocking-brain_s-internal-marijuana-may-trigger-early-alzheimers.html

 

 

 

15430_iStock_000006935624Small1.jpg

 

 

Clumps of protein in the brain, called beta-amyloid plaques, are the primary marker of Alzheimer’s disease. For long, scientists knew that these clumps interfered with memory signals in the brain — but they weren’t sure how.

Now a team from Stanford University School of Medicine has traced the effects of beta-amyloid plaque to activity of the brain’s endogenous cannabinoids, or endocannabinoids. These compounds are produced naturally by the brain and mimic the effects of compounds in cannabis. Among many functions, cannabinoids play a key role in memory and learning.

“Endocannabinoids in the brain are very transient”Looking at brain slices taken from rats, the researchers observed that clumps of beta-amyloid indirectly impaired memory pathways by interfering with the normal activity of cannabinoids.

This interference with the brain’s cannabinoids may be the mechanism by which early memory deficits in Alzheimer’s are formed, says Daniel Madison, PhD, who led the study. Cannabinoids may also present a new opportunity for treating Alzheimer’s before the disease advances, he adds.

The findings were published June 18 in the journal Neuron.

However, Dr. Madison says it would be inaccurate to assume that smoking cannabis could counteract the effects of beta-amyloid plaque on memory and learning.

“Endocannabinoids in the brain are very transient and act only when important inputs come in,” explains Dr. Madison. Marijuana’s main ingredient, THC, has a much longer-lasting effect, he notes.

“Exposure to marijuana over minutes or hours is different: more like enhancing everything indiscriminately, so you lose the filtering effect. It’s like listening to five radio stations at once.”

On the other hand, a 2013 study by researchers from Neuroscience Research Australia suggests an ingredient in marijuana called CBD could be beneficial. The team, led by Tim Karl, PhD, found that treatment with CBD led to drastic improvements in memory in mice genetically engineered to mimic Alzheimer’s disease.

Besides the potential to combat Alzheimer’s symptoms, some studies suggest cannabinoids also hold promise in slowing progression of the disorder.

 

Share this post


Link to post
Share on other sites

Well, my grandparents always thought I was the devil for smoking the herb, now one has Alzheimers. I guess got the last laugh :LOL: 


Disappointment is caused by unrealistic expectations. / The more I learn about people the more I like my dog. / Whether you think that you can, or that you can't, you are usually right. / Its like everything it depends on everything else. 

 

 

 

 

Share this post


Link to post
Share on other sites

Hey Buddy... I'm Gonna Make This Topic A Tab.

I Want To Read Every Link Above. Thanks Brother Very Much-So True You Really Know Your Stuff !

Man That Was My Thing Too. I Read Everything I Could Get My Hands On.

That's How My Youngest Daughter Became An R.N. And With My Son's Girlfriend We'll Have Another R.N.

In About A Year. My Daughter As A Young Child Came Up To Me One Day And Told Me And Mom

How Much She Wanted To Help People... She Took Off Like A Rocket From Approx 10 Yrs Old !

 

Good Night My Brother And Everyone... Sincerely Grateful, Will

Share this post


Link to post
Share on other sites

The Sanford Study Is Really Heavy. I'm Going To Keep Coming Back Until I Connect Everything Up.

Seems Like It's The Only Part Of My Brain That Works When I Read Just About Anything Medical.

Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice

I Like This 2013 Study Too.

 

Abstract

Rationale

Patients suffering from Alzheimer’s disease (AD) exhibit a decline in cognitive abilities including an inability to recognise familiar faces. Hallmark pathological changes in AD include the aggregation of amyloid-β (Aβ), tau protein hyperphosphorylation as well as pronounced neurodegeneration, neuroinflammation, neurotoxicity and oxidative damage.

Objectives

The non-psychoactive phytocannabinoid cannabidiol (CBD) exerts neuroprotective, anti-oxidant and anti-inflammatory effects and promotes neurogenesis. CBD also reverses Aβ-induced spatial memory deficits in rodents.

Materials and methods

Thus we determined the therapeutic-like effects of chronic CBD treatment (20 mg/kg, daily intraperitoneal injections for 3 weeks) on the APPswe/PS1∆E9 (APPxPS1) transgenic mouse model for AD in a number of cognitive tests, including the social preference test, the novel object recognition task and the fear conditioning paradigm. We also analysed the impact of CBD on anxiety behaviours in the elevated plus maze.

Results

Vehicle-treated APPxPS1 mice demonstrated impairments in social recognition and novel object recognition compared to wild type-like mice. Chronic CBD treatment reversed these cognitive deficits in APPxPS1 mice without affecting anxiety-related behaviours.

Conclusions

This is the first study to investigate the effect of chronic CBD treatment on cognition in an AD transgenic mouse model. Our findings suggest that CBD may have therapeutic potential for specific cognitive impairments associated with AD.

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

On 6/26/2014 at 3:42 PM, EDDIEKIRK said:

The team, led by Tim Karl, PhD, found that treatment with CBD led to drastic improvements in memory in mice genetically engineered to mimic Alzheimer’s disease.

Drastic Far-Out !

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Oh Darn, I Passed Over The 'Neuron' Link And Then Went Back A Few Minutes Ago. Short But Super Interesting.

----------------------------------------------------------------------------------------------------------------------------------------------------

On 6/26/2014 at 3:42 PM, EDDIEKIRK said:

Besides the potential to combat Alzheimer’s symptoms, some studies suggest cannabinoids also hold promise in slowing progression of the disorder.

Even More Good News... I Wonder Where The Studies Are Now Around The World ? I Must Find A Good Day Or Three

To Search About For Up To Date Studies... Just Think With All The Access To Cannabis And The Cannabinoids Themselves Specifically...

New Research Should Really Get The Knowledge Juices Flow'in Eh ?

 

Thanks Very Much EK... Most Sincerely, BW

Share this post


Link to post
Share on other sites

×