Jump to content

Brother Will

  • Content count

  • Joined

  • Last visited

  • Days Won


Brother Will last won the day on July 14 2015

Brother Will had the most liked content!

1 Follower

About Brother Will

  • Rank
    Brother Will

Profile Information

  • Gender
  • Location
    PDX Reed College/My Medical Card Is Still Good Though 1-23-18/Only Missed One Year Since Our OMMP Program Started.
  • Interests

Recent Profile Visitors

597 profile views
  1. Jump over to our PM, I found one of your notifications off. 

  2. The 'Will's' 2nd batch is an 8 out of 10, Thanks

  3. The 'Will's' 2nd batch is an 8 out of 10, Thanks

  4. If It Wasn't For Your Post Here Sister Purple I Wouldn't Have Found This Original Study. Watch-Out It's Long But Very Well Done/Thanks Very Much. My Daughter Had Her Baby And She's Really Interested. Here Is The Original Study... Or Go Here-> http://cannabisclinicians.org/wp-content/uploads/2012/03/Dreher-Pediatrics.pdf Pediatrics, February 1994, Volume 93, Number 2, pp. 254-260. American Academy of Pediatrics From the Schools of Nursing, Education, and Public Health, the University of Massachusetts, Amherst. Received for publication Sep 21, 1992; accepted Jun 30, 1993. Reprint requests to (M.D.) School of Nursing, the University of Massachusetts, 111 Arnold House, Amherst, MA 01003. Pediatrics (ISSN 0031 4005). Copyright © 1994 by the American Academy of Pediatrics. Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica: An Ethnographic Study Melanie C. Dreher, PhD; Kevin Nugent, PhD; and Rebekah Hudgins, MA ABSTRACT. Objective. To identify neurobehavioral effects of prenatal marijuana exposure on neonates in rural Jamaica. Design. Ethnographic field studies and standardized neurobehavior assessments during the neonatal period. Setting. Rural Jamaica in heavy-marijuana-using population. Participants. Twenty-four Jamaican neonates exposed to marijuana prenatally and 20 nonexposed neonates. Measurements and main results. Exposed and nonexposed neonates were compared at 3 days and 1 month old, using the Brazelton Neonatal Assessment Scale, including supplementary items to capture possible subtle effects. There were no significant differences between exposed and nonexposed neonates on day 3. At 1 month, the exposed neonates showed better physiological stability and required less examiner facilitation to reach organized states. The neonates of heavy-marijuana-using mothers had better scores on autonomic stability, quality of alertness, irritability, and self-regulation and were judged to be more rewarding for caregivers. Conclusions. The absence of any differences between the exposed on nonexposed groups in the early neonatal period suggest that the better scores of exposed neonates at 1 month are traceable to the cultural positioning and social and economic characteristics of mothers using marijuana that select for the use of marijuana but also promote neonatal development. Pediatrics 1994;93:254- 260; prenatal marijuana exposure, neonatal outcomes, Jamaica, Brazelton scale supplementary items. ABBREVIATIONS. NBAS, Neonatal Behavioral Assessment Scale; SES, Socioeconomic status. The purpose of this study was to identify the effects of marijuana (or "ganja" as it is called in Jamaica) consumption during pregnancy and lactation on offspring during the neonatal period. Despite the prevalence of marijuana use among women of childbearing age, 1-3 reports on the behavioral teratogenic effects of prenatal marijuana exposure have been conflicting and inconclusive. Fried and Makin, 4 for example, found that moderate levels of marijuana use in their middle-class Ottawa sample (7.0 joints per week) were associated with poorer habituation to light, higher levels of irritability, and increased tremors and startles as assessed by the Brazelton Neonatal Behavioral Assessment Scale (NBAS) between the third and sixth days of life. Tennes et al, 5 on the other hand, found no relationship between exposure to marijuana and the neonates' behavior as rated by the NBAS. Similarly, a recent study of 373 lower socioeconomic status (SES) mothers and their neonates by Richardson and colleagues 6 found no relationship between moderate levels of marijuana use during pregnancy and neonate behavior on the NBAS on the second day of life. Yet Chasnoff, 7 lending support to Fried's findings, observed that marijuana use during pregnancy made a significant contribution to variance in the Brazelton State Regulation cluster scores, including habituation, in neonates a few days of age. More recently, Coles et al, 8 studied the effects of maternal drug use on the neurobehavioral status of 107 neonates and found maternal marijuana use had depressed effects on the Orientation cluster of the NBAS at 14 days and on the Range of State cluster at the end of the first month. The interaction of marijuana use and cocaine and alcohol, however, was responsible for significant amounts of the variance in neonate behaviors over the first month of life. Nevertheless, they concluded that although the influence of drug and alcohol exposure could be noted statistically, the effects on neonate behavior were small and behavior was not clinically aberrant. It is likely that many of conflicting results among published studies on the effects of prenatal drug exposure are due to methodological problems in (1) the measurement of neonatal outcomes and (2) the context in which the research is conducted. With the exception of the analysis of cries of neonates in Jamaica 9 and the work of Scher et al 10 and Dahl et al 11 that demonstrated altered sleep cycling and motility among North American neonates, most research has used the Brazelton Neonatal Behavioral Assessment Scale as an outcome measure in examining the effects of prenatal drug exposure. Inconsistencies in the use of the scale, however, have included the timing of the administration, the degree to which examiners were trained to reliability, 12, 13 and the approach to data reduction and analysis. Perhaps most important, only the 28 neurobehavioral items on the NBAS have been used in any analysis to date. Although supplementary items were added to the second edition of the Brazelton Neonatal Behavioral Assessment Scale 12 to be used with high-risk or fragile neonates, the items have not yet been employed in any published study of the effects of in utero drug exposure. This may mean that the more subtle differences that could distinguish marijuana-exposed neonates simply may not have emerged in the traditional scoring schemes and neurobehavioral cluster analysis. With regard to the research context, it should be noted that virtually all the studies of prenatal exposure have been conducted in the United Sates and Canada where marijuana use is primarily recreational. This is in marked contrast to other societies, such as Jamaica, where scientific reports have documented the cultural integration of marijuana and its ritual and medicinal as well as recreational functions. 14, 15 Previous studies have had difficulty controlling possible confounding effects of factors such as polydrug use, antenatal care, mothers' nutritional status, maternal age, SES and social support, as well as the effects of different caretaking environments, which could lead to differences in neonate behavior. 8, 16 The legal and social sanctions associated with illicit drug use often compromise self-report data and render it almost impossible to obtain accurate prenatal exposure levels. 17 The Jamaican perinatal marijuana study provides a unique opportunity to address several of these methodological issues. First, although the study employed the NBAS to assure comparability with other studies, it was assumed that the full-term scale might not be sensitive to less obvious effects of risk status. Because the effects of marijuana were expected to be subtle, 4 and because the results of studies using the NBAS to examine the effects of substance abuse on neonatal behavior have been inconclusive, 6, 8, 16 the new supplementary items were administered to better capture the more latent effects of maternal marijuana use on neonatal behavior. In Jamaica the use of marijuana is culturally integrated and governed by social rules that guide consumption and distribution and inhibit abuse. 14, 15 Because the cultural meanings that attend marijuana use and users have been documented to influence the outcomes of consumption, 14, 18 the Jamaican study permits cross-cultural scrutiny of the concepts and assumptions formulated in Eurocentric cultures. Also unlike the United States and Canada where polydrug use prevails, marijuana use by women in Jamaica has been relatively uncontaminated by other drugs; even alcohol and tobacco are used only minimally by women. 14, 15, 18, 19 Furthermore, conducting the study in one rural parish (county) provided an opportunity to compare users and nonusers who are drawn from the same population in which there is little variation in such factors as nutrition and prenatal care. Finally, field workers resided in the communities and developed long-term, trusting relationships with participants. This enhanced the credibility of self-reports of consumption and permitted confirmation by direct observations of marijuana-linked behavior. Previously reported findings from this study suggested a biological vulnerability associated with prenatal exposure to marijuana in the immediate postnatal period. 9 This paper explores the influence of the cultural context of caregiving by evaluating the infants both at the beginning and the end of the neonatal period with assessment measures specifically designed to capture the subtle effects of maternal marijuana use on neonatal behavior. CULTURAL CONTEXT This project was based in the southeastern part of Jamaica in which there is a wellknown and documented widespread use of marijuana. 19 Consistent with the working class throughout Jamaica, residents in the rural communities from which the sample for this study is drawn view marijuana not only as a recreational drug but one that also has ritual and medicinal value. Rastafarians, members of a political-religious movement that endorses marijuana as a sacred substance, may smoke ritually on a daily basis. Marijuana also is known for its therapeutic and health-promoting functions. It is consumed as a tea by family members of all ages for a variety of illnesses and to maintain and promote health. 14, 15 Although the consumption of marijuana tea transcends class, age, and gender divisions, marijuana smoking traditionally has been an adult male, working class activity. 14, 15 The female marijuana smoker was a rarity and the few women who engaged in smoking were considered base and undignified and often held in contempt by both men and women. Instead, women prepared marijuana for themselves and their families in the form of teas and tonics. More recently, however, increasing numbers of women have begun to smoke marijuana regularly. 20 To some extent, this was attributed to the increasing participation of women in Rastafarianism, but the practice has spread to nonRastafarian women as well. Not only are such women now grudgingly tolerated by their communities, many of the heavy-marijuana-users, particularly if they were Rastafarians, have been given the commendatory title of "Roots Daughter." Roots Daughters are described as women "with a purpose," who can "think, reason and smoke like a man" and who are self-reliant and dignified. They smoke marijuana on a daily basis, in a manner not unlike that of their male counterparts, and continue to smoke during pregnancy and the breast-feeding period. Although marijuana use during pregnancy is discouraged in prenatal clinics and through government-sponsered prevention programs, the consumption of marijuana during pregnancy by Jamaican women is not necessarily indicative of a mother's lack of concern about the health and development of her infant. Supported by the folk belief that marijuana has health-rendering properties and by the experience of relatives and neighbors, women use it as a vehicle for dealing with the difficult circumstances surrounding pregnancy and childbirth. For instance, 19 of the marijuana smokers in the sample reported that it increased their appetites throughout the prenatal period and / or relieved the nausea of pregnancy. Fifteen reported using it to relieve fatigue and provide rest during pregnancy. All the mothers considered the effects of marijuana on nausea and fatigue to be good for both themselves and their infants. The responsibilities that accompany pregnancy and infant care in an unyielding economic environment are not trivial. The multigravidas, in particular, reported that the feelings of depression and desperation attending motherhood in their impoverished communities were alleviated by both social and private smoking. Despite these reports of the benefits of marijuana to both mother and baby, the women who smoke marijuana with any regularity continue to be in the minority. Most women in Jamaica refrain from smoking the substance and those who do smoke marijuana represent a departure from the norms regarding standard female behavior. 20 METHOD An ethnographic design, combining community and household naturalistic observations and interviews of 60 women with standardized testing of their neonates using the NBAS, was employed. With the assistance of local midwives, the field workers identified and recruited pregnant women who used marijuana until a sample of 30 was obtained. After each participant agreed to participate and informed consent was obtained, she was then matched (again, with the assistance of local midwives) with a gravid woman who did not use marijuana, according to age, parity, and SES. The study was fully explained to both the marijuana users and the companion group and none refused to participate. During the course of the study, three of the mothers designated as nonusers were discovered to be tea drinkers and were transferred to the users category, resulting in a sample of 33 users and 27 nonusers. Further losses to the sample include two spontaneous abortions in the users category and one stillbirth and a preterm in the nonuser category, yielding a maternal sample of 31 users and 25 nonusers. Social, medical, and obstetrical histories were determined via maternal interviews. Naturalistic observations of the women in their homes and communities were conducted by the field workers who maintained routine contact with the participants throughout the prenatal period. Data concerning labor and delivery and the status of the neonate, details of labor, any anomalies or complications, birth weight, and length of gestation were abstracted from hospital records for each birth event. The sample was drawn from the vast category of "rural poor," which constitute the majority of the population of this region of Jamaica. The two groups were matched for SES, based on income and employment, parity (0 to 8 for both smokers and nonsmokers) and age . The 60 women ranged in age from 15 to 42 and all were of Afro-Jamaican descent. None were gainfully employed in permanent jobs although many worked occasionally outside their homes as agricultural or domestic laborers or as "higglers" (vendors). Only one of the women was legally married, although more than half of the women were living in a more or less permanent common-law arrangement with their infant's father. Three of the women were members of a Rastafarian sect and lived in a communal "Rasta Camp." All had regular prenatal care from at least the second trimester to birth. The use of alcohol and tobacco was minimal in both groups and did not exceed 3 beers or 15 tobacco cigarettes per week for any of the women in the study. Based on self reports, reports of community residents and direct observations by field workers, the group of marijuana-using mothers was further designated as "light," "moderate," or "heavy" users, depending on the frequency the amount of use. Light users were defined as those women who consumed marijuana tea only or smoked infrequently, averaging less than 10 cigarettes per week. Moderate users were those women who smoked 3 or more days a week, averaging between 11 and 20 marijuana cigarettes. Heavy users smoked daily, usually more than 21 marijuana cigarettes per week. Many moderate and heavy users also were regular marijuana tea drinkers. Although it was not by design, the user group was divided into almost equal categories of heavy (n = 10), moderate (n = 9), and light (n = 12). Although the sample was matched on three major variables, the social histories revealed subtle and unanticipated differences both within the using group and between the two groups. First, as a group, the heavy users had the highest level of education. All the heavy users had had some schooling beyond the primary school level and three had had some post secondary training. Although SES was a matching variable in the selection of the sample, the roots daughters (heavy-marijuana-users) were distinguishable by the source of support. None relied exclusively on the father of the study child for support whereas most of the sample was either solely or heavily dependent on their infant's father. Although none of the women in the sample was routinely employed, the alternative sources of income for the roots included their own cash-generating activities such as running an illegal gambling operation or selling marijuana, remittances from relatives living abroad, support from parents or from former mates in the form of cash, food, housing, clothing and/or child care, and for the three Rastafarian women, housing and food in a communal living arrangement. The heavy-marijuana-users did not have more income and status than the other women, but they did have more control over how they acquired and spent their resources. Closely linked to this greater economic independence is the lower level of conjugal stability among users compared with nonusers. Because they did not rely on male support, they were relatively free to separate and form new relationships if their current relationship was not to their liking. 21 Among the women using marijuana heavily, only 48% were in common-law unions compared with 71% of the nonusing women. Among the 10 heavy-marijuana-users, only 3 lived in more or less permanent, co-residential relationships with the fathers of their infants. The remaining seven maintained their own households, although 3 were visited regularly by their infant's father. Newborn Assessments The newborn assessments were administered in the hospital on the first and third days and at 1 month of the newborn's life in the hospital maternity ward. To keep the conditions of birth as comparable as possible, only those newborns who were born in the hospital and remained there for 3 days were included in the analysis. Therefore, although the maternal sample was 31 users and 25 nonusers the newborn sample was reduced to 24 exposed and 20 nonexposed newborns. The Jamaican examiner, who was blind to the neonates group assignment, was a registered nurse who had worked for several years on the maternity unit and was trained by the Child Development Unit Harvard Medical School both to the .90 reliability criterion and to administer the NBAS supplementary items. 12 Three examination data collection points were used to embrace the entire neonatal period: 1 day, 3 days, and 1 month. Given the great disparity within the sample regarding the timing and place of birth, the day assessments were omitted from the analysis because of possible differences in recovery time, in keeping with the recommendations of the NBAS manual. 12 Based on the developmental assumptions underlying the NBAS, 13 the assessment of neonate behavior at the end of the first month also can provide a functional assessment of the effects of the caregiving environment on neonate behavior. The Brazelton scores at the end of the first month, therefore, can be interpreted not only in terms of direct marijuana effects but also as a result of the effects of the environment on behavior. 12 The supplementary items assess behavior such as the quality of the neonate's attention or the cost of this level of responsivity to the neonate's physiological or motor system. The supplementary items also assess the extent of examiner effort that may be necessary to facilitate the neonate's performance. This, in turn, may be a critical area that differentiates the fragile neonate, who has difficulty in coping with the demands of the examination, from the less stressed, healthy neonate. These additional supplementary items also identify the threshold of responsivity in neonates and the degree to which they are vulnerable to external environmental stimulation. Quality of Alert Responsiveness is an assessment of the overall capacity of the neonate to respond to both human and nonhuman stimuli. Cost of Attention describes the degree to which the neonate's motor, state, and physiological systems are stressed or compromised as the neonate interacts with the environment. Examiner Persistence is a measure of the amount of examiner facilitation that is necessary to enable the neonate to maintain homeostasis or to be able to respond optimally to the challenges of the examination. General irritability is an extension of the irritability item in the Scale proper and describes the overall amount of fussing or crying during the course of the examination. The Robustness and Endurance item assesses the degree to which neonates become exhausted or stressed during the course of the assessment or the extent to which their "energy" resources enable them to organize or recover in the face of stress. The Regulatory Capacity score is an index of the strength of the regulatory system and of the neonate's ability to self-regulate. State Regulation provides a measure of the range of the neonate's six states and the degree to which the states are robust and stable and contribute to the overall organization of the neonate. Balance of Motor Tone Examines the consistency of motor tone throughout the body and is demonstrated by the balance between the flexor and extensor motor groups. The final item, Reinforcement Value of the Infant's Behavior, is a measure of the examiner's reaction to the neonate and a clinical rating of the degree to which the neonate was easy or difficult to manage through the course of the examination. Of these nine items, only Regulation of State and the Cost of Attention items were not scored. On the basis of the individual item scores, each subject was assigned a score for each of the seven clusters, and a score for each of the seven summary supplementary items. For the analysis of the NBAS data, the 3-day and 1-month individual scores were reduced to the seven clusters described by Lester et al. 22 These clusters and the supplementary items were used as dependent measures in the subsequent analyses. The clusters are Habituation, Orientation, Motor Organization. Range of State, Regulation of State, Autonomic Regulation, and the number of Abnormal Reflexes. The groups were first dichotomized into marijuana-exposed versus nonexposed and, using SPSS-X statistical software,The tests were performed to compare the performance of these neonates on the NBAS clusters and on the supplementary items. Because the neonates of the heavy users received the most frequent and consistent exposure both prenatally and during the first month of life they served as the "extreme" cases in which to search for specific developmental and behavioral effects. To examine these effects, the scores of the neonates of heavy-marijuana-using and neonates of nonusing mothers were also compared using t tests. RESULTS The course of the pregnancies were similar in each group and the two groups of neonates were not significantly different according to physical examination data, including birth weight and length and gestational age. 23 Because Apgar scores were not recorded by hospital nurses at standard time intervals, they were less reliable. Nevertheless, there were no significant differences in the Apgar scores between the two groups. t tests were used to compare the performance of neonates of users (n = 24) and nonusers (n = 20 on the NBAS cluster scores and on the supplementary items on the third day of life. Table 1 shows that there were no significant differences on the seven clusters. There also were no differences on the seven supplementary items. To examine the degree to which heavy marijuana use may have an effect on neurobehavioral outcome, we then compared the performance of the heavily exposed and nonexposed neonates on the NBAS on day 3, by examining group differences on the seven Brazelton cluster scores and on the supplementary items scores. As Table 2 reveals, there were no significant differences in performance on the Brazelton cluster scores on day 3. Similarly, no differences were found on the supplementary item summary scores. At 1 month, however, comparisons between exposed and nonexposed neonates revealed that the neonates of using mothers had significantly higher scores on the Autonomic and Reflex clusters of the NBAS (see Table 3). On the supplementary items, these neonates scored higher (were less irritable) on the General Irritability item. Comparing the heavily exposed and the nonexposed infants, the Brazelton clusters on day 30, showed that the offspring of heavy-marijuana using mothers had significantly higher scores on the Orientation cluster, on the Autonomic Stability cluster, and on Reflexes (see Table 4). Due to the intercorrelation among the variables comprising each cluster, no t scores or P values are reported for individual items. Nevertheless, a comparison of individual item scores showed that neonates of heavy users had higher scores on habituation to auditory and tactile stimuli, and to animate auditory stimuli, the degree of alertness, capacity for consolability, irritability (ie, less irritable), and had fewer startles and tremors. The comparisons on the supplementary items revealed significant differences on all seven variables, with the neonates of mothers who were heavy-marijuana users performing more optimally on these items. DISCUSSION Although no positive or negative neurobehavioral effects of prenatal exposure were found at 3 days of life using the Brazelton examination, there were significant differences between the exposed and nonexposed neonates at the end of the first month. Comparing the two groups, the neonates of mothers who used marijuana showed better physiological stability at 1 month and required less examiner facilitation to reach an organized state and become available for social stimulation. The results of the comparison of neonates of the heavy-marijuana-using mothers and those of the nonusing mothers were even more striking. The heavily exposed neonates were more socially responsive and were more autonomically stable at 30 days than their matched counterparts. The quality of their alertness was higher; their motor and autonomic systems were more robust; they were less irritable; they were less likely to demonstrate any imbalance of tone; they needed less examiner facilitation to become organized; they had better self-regulation; and were judged to be more rewarding for caregivers than the neonates of nonusing mothers at 1 month of age. TABLE 1. Neonatal Behavioral Assessment Scale Cluster and Supplementary Scores, Day 3 Users Nonusers t Score (n = 24) (n = 20) ------------- -------------- Mean SD Mean SD Habituation 6.83 0.804 6.82 0.835 -.06 Orientation 5.87 0.953 5.45 1.324 -1.10 Motor organization 5.39 0.576 5.42 0.405 0.22 Range of state 4.15 0.415 4.07 0.474 -.57 Regulation of state 5.43 1.163 5.73 0.664 1.06 Autonomic stability 7.59 1.350 7.41 2.020 -.35 Reflexes 15.15 2.240 13.82 3.264 -1.47 Quality of alertness 5.69 1.692 6.05 1.298 0.80 Robustness 7.46 0.811 7.64 1.115 0.59 Regulatory capacity 5.80 1.767 6.00 1.458 0.39 Motor tone 6.76 0.992 6.94 1.249 0.48 General irritability 7.70 0.806 7.75 0.447 0.21 Examiner's persistence 5.42 1.653 5.58 2.002 0.28 Reinforcement value 5.88 1.451 5.94 1.435 0.13 TABLE 2. Neonatal Behavioral Assessment Scale Cluster and Supplementary Scores, Day 3 Heavy users Nonusers t Score (n = 10) (n = 20) ------------- -------------- Mean SD Mean SD Habituation 6.45 0.683 6.82 .835 1.10 Orientation 5.87 0.655 5.45 1.324 -1.05 Motor organization 5.42 0.484 5.42 0.405 0.01 Range of state 4.13 0.427 4.07 0.474 -.31 Regulation of state 5.43 0.836 5.73 0.664 0.93 Autonomic stability 8.13 1.200 7.41 2.020 -1.18 Reflexes 15.66 2.180 13.82 3.264 -1.72 Quality of alertness 5.77 1.856 6.05 1.298 0.40 Robustness 7.22 0.441 7.64 1.115 1.38 Regulatory capacity 5.33 1.871 6.00 1.458 0.93 Motor tone 6.77 1.093 6.94 1.249 0.34 General irritability 7.85 0.378 7.75 0.447 -.59 Examiner's persistence 6.00 1.581 5.58 2.002 -.57 Reinforcement value 5.77 1.716 5.94 1.435 0.24 TABLE 3. Neonatal Behavioral Assessment Scale Cluster and Supplementary Scores, One Month Users Nonusers t Score (n = 24) (n = 20) ------------- -------------- Mean SD Mean SD Habituation 7.20 0.877 6.53 1.503 -1.50 Orientation 6.63 1.439 6.45 1.310 -.45 Motor organization 6.45 0.669 6.36 .715 -.41 Range of state 3.88 0.748 4.03 .614 0.80 Regulation of state 5.62 1.074 5.47 1.415 -.39 Autonomic stability 8.69 0.549 7.33 2.260 -2.63* Reflexes 15.55 1.88 13.40 2.990 -2.85* Quality of alertness 7.28 1.357 6.65 1.496 -1.51 Robustness 8.78 0.499 8.47 .841 -1.45 Regulatory capacity 7.00 1.633 6.15 1.725 -1.72 Motor tone 7.46 1.105 7.50 0.513 0.15 General irritability 8.37 0.565 7.75 0.716 -3.20* Examiner's persistence 7.25 1.666 6.55 1.877 -1.33 Reinforcement value 7.28 1.512 6.70 1.418 -1.37 * P <(on top of) (symbol) .01. Cry changes reported for this population 9 had suggested a biological vulnerability 24 in the immediate postnatal period that was not evident in the supplementary item results of this study. A possible explanation for this discrepancy is that the Brazelton supplementary items, conducted under more controlled conditions, simply provided a more comprehensive and reliable assessment of the neonates' neurobehavioral status. It also is possible that the social effects 25 of the neonate's cry characteristics may even have elicited a quality of caregiver responses that could contribute to better outcomes at 1 month. It should be pointed out that Coles et al 8 also reported more significant differences at 1 month on the Brazelton Scale clusters than at earlier assessments, suggesting environmental effects. In this case, the direction of the differences in performance on the Brazelton examination between 3 days and 1 month suggest not only that the environment may be more influential than prenatal exposure in predicting outcomes but that the environment of the exposed group may be superior to that of the nonexposed group. Conventional wisdom would suggest that mothers who are long-term marijuana users are less likely to create optimal caregiving environments for their neonates. In this area of rural Jamaica, however, where marijuana is culturally integrated, and where heavy use of the substance by women is associated with a higher level of education and greater financial independence, it seems that roots daughters have the capacity to create a postnatal environment that is supportive of neonatal development. Indeed, Pearson's correlations, performed determine whether there was an association between the mother's education and neonatal outcomes at 1 month, revealed that maternal education was significantly correlated with the Autonomic cluster at 1 month (r = .27, P = .031) and approached significance with all the supplementary items. Although it is tempting to explain the 1-month outcomes by simply appealing to the correlation evidence linking performance to maternal characteristics, the question remains as to how these characteristics are translated to the formation of a better environment for neonatal development, particularly given the higher level of conjugal instability among users. Ethnographic observations of the postnatal environments identified that, despite the higher level of single mother households among the users, they had fewer children at home and thus fewer child care responsibilities compared with their nonusing counterparts. They also had more adults living in their households. Pearson's correlations revealed that the household child / adult ratio was significantly correlated with the Habituation clusters at 1 month (P = .046, r = .30) and with later child development outcomes. 21 Although the exact mechanism linking child / adult ratio to 1 month outcomes requires further delineation, it is possible that with more adults present to assist the mother and respond to the neonate and / or with fewer children to compete for attention, the mother is better equipped to facilitate the neonate's interaction with his / her environment. The lower child / adult household ratios and the mother's characteristics are not unrelated. The dispersal or outplacement of older children to their respective father's households as a new child is brought in is a common practice, facilitated by the pattern of serial mating in which the using mothers are more likely to engage. Thus, in this Jamaican rural working class context, conjugal instability is associated with greater rather than diminished access to the resources that influence child development. TABLE 4. Neonatal Behavioral Assessment Scale Cluster and Supplementary Scores, One Month Heavy users Nonusers t Score (n = 10) (n = 20) ------------- -------------- Mean SD Mean SD Habituation 6.75 1.521 6.53 1.503 -.22 Orientation 7.40 0.457 6.45 1.310 -2.87+ Motor organization 6.33 0.374 6.36 0.715 0.16 Range of state 3.41 0.984 4.03 0.614 1.75 Regulation of state 6.20 1.007 5.47 1.415 -1.57 Autonomic stability 9.00 0 7.33 2.260 -3.30+ Reflexes 15.78 2.220 13.40 2.990 -2.38* Quality of alertness 8.00 0.500 6.65 1.496 -3.61+ Robustness 9.00 0.000 8.47 .841 -2.73+ Regulatory capacity 7.77 1.093 6.15 1.725 -3.07+ Motor tone 7.88 0.333 7.50 .513 -2.44* General irritability 8.75 0.463 7.75 .716 -4.37+ Examiner's persistence 8.33 0.707 6.55 1.877 -3.70+ Reinforcement value 8.00 0.707 6.70 1.418 -3.29+ * P <(on top of) (symbol) .03. + P <(on top of) (symbol) .01. Cross-societal research 14, 15, 26 has identified the importance of understanding the cultural context of drug use to explain outcomes. Whether or not the effects of marijuana during the prenatal period are real or only perceived, it is clear that for them, it has at least symbolic value in assisting them through the physical, social, and psychological difficulties of pregnancy and the postnatal experience. Furthermore, unlike the United States, in which heavy marijuana use often is associated with maternal incompetence and a suboptimal caregiving environment, the data from this study indicate that in Jamaica, the heavy-marijuana-using mother's education, independence, and greater access to resources converge in a constellation of maternal competence and a supportive context for neonatal development. Strengths and Limitations It should be noted that there are several limitations posed by this study and caution must be used in interpreting the results. First, the means by which the study participants were recruited may have introduced a bias in the sample. Second, the sample size is small, obviating the use statistical procedures that might be able to account for the many environmental variables that seem to influence some of the outcomes. Third, in a prospective study of this nature it is impossible to foresee and control for all the potential environmental and maternal confounders. Finally, this study has not eliminated alternative explanations. It is possible for example, that the outcomes at 1 month are related to neonatal exposure to marijuana constituents via breast milk or to prenatal influences that simply were not manifested at the 3-day examination. On the other hand, the prospective design, using ethnographic techniques and inductive analyses, offers several advantages to the exploration of prenatal exposure to illicit drugs. First, given the difficulties encountered in recruiting participants who are engaging in an illegal activity and then retrieving credible data from them, identification by fieldworkers, with assistance from local midwives, represented a contributive alternative to a random sampling strategy. Second, although the sample size is small, it provided an opportunity to follow up drug-using women through pregnancy with the level of detail that often is lacking in retrospective studies of large numbers of women. Finally, the effects of prenatal exposure to drugs such as marijuana depend on several factors for which it is difficult and sometimes impossible to control in most clinical investigations. 8 Although this study was successful in controlling for polydrug use and SES, other variables (financial independence, mothers education, and household child / adult ratio) emerged as meaningful during the course of this study. Indeed a strength of the inductive design is its capacity to identify such unanticipated variables and to understand how they are linked in Jamaican culture with heavy marijuana use and a roots daughter syndrome. Although some might interpret this failure to identify the relevant variables at the outset of the study and control for them in a more experimental design as a weakness of the study, one could argue, conversely, that the project's greatest value is its capacity for discovery and the generation of hypotheses and research questions that can be explored in subsequent studies. ACKNOWLEDGMENT This work was supported by the March of Dimes Foundation. REFERENCES 1. Negrete JC. What's happened to the cannabis debate? Br J Addiction. 1988:83:359-372 2. Schwartz RH. Passive inhalation of marijuana, phencyclidine, and freebase cocaine ('crack') by infants. Am J Dis Child. 1989:143:644 3. Zuckerman B. Frank. DA, Hingsem R, et al. Effects of maternal marijuana and cocaine use on fetal growth. New Engl J Med. 1989:32D:763-768 4. Fries PA, Makin JE. Neonatal behavioral correlates of prenatal exposure to marijuana, cigarettes and alcohol in a low risk population. Neurotoxicol Teratol. 1987:9:1-7 5. Tennes K, Avitable N, Blackard C, et al. Marijuana: prenatal and postnatal exposure in the human. In: Pinkert TM, ed. Current Research on the Consequences of Maternal Drug Abuse. Washington DC: US Government Printing Office: 1985. NIDA Research Monograph No. 59. 6. Richardson GA, Day NL, Taylor PM. The effect of prenatal alcohol, marijuana, and tobacco exposure on neonatal behavior. Infant Behav Dev. 1989:12:199-209 7. Chasnoff IJ. Cocaine use in pregnancy: effect on infant neurobehavioral functioning. Presented at the American Society for Pharmacology and Experimental Therapeutics, 1990, Washington DC 8. Coles CD, Platzman KA, Smith I, James ME, Falek A. Effects of cocaine, alcohol, and other drug use in pregnancy on neonatal growth and neurobehavioral status. Neurotoxicol Teratol. 1992:14:22-33 9. Lester B, Dreher M. Effects of marijuana use during pregnancy on newborn cry. Child Dev. 1989:(?):765-771 10. Scher MS, Richardson GA, Cuble PA, et al. The effects of prenatal alcohol and marijuana exposure: disturbances in neonatal sleep cycling and arousal. Pedatr Res. 1984:24:101-105 11. Dahl RE, Scher MS, Day NL, et al. The effects of prenatal marijuana exposure evidence of BEG sleep disturbances continuing through 3 years of age. Dev Behav Pediatr. 1989:19:264 Abstract 12. Brazelton TB. The Neonatal Behavioral Assessment Scale. Philadelphia: JB Lippincott: 1984 13. Brazelton TB, Nugent KJ, Lester BM. The neonatal behavioral assessment scale. In; Osafsky J, ed. The Handbook of Infant Development. New York; Wiley; 1987 14. Rubin V, Comitas L. Ganja in Jamaica. The Hague: Mouton Press; 1975 15. Dreher M. Working Men and Ganja. ISHI; 1982 16. Zuckerman B, Hingson R. Alcohol consumption during pregnancy. Dev Med Child Neurol, 1987;28:6-19-653 17. Hingson R, Zuckerman B, Amaro H, et al. Maternal marijuana use and neonatal outcomes; uncertainty posed by posed by self-reports. Am J Public Health. 1986;76:667-669 18. Dreher M. School children and ganja. Anthropol Educ Q. 1984;15:131-150 19. Clayton RR, Lindblad R, Walden KP, Knight F, Campbell E, Eldemire D. Drug use and drug abuse in Jamaica: the 1987 Jamaica national household survey. Sponsored by USAID and the National Council on Drug Abuse, Government of Jamaica, through the Pan America Health Organization, 1988 20. Dreher M. The evolution of a roots daughter. J Psychoactive Drugs. 1987;19:165- 170 21. Dreher M, Gilbert D, Hudgins R. Conjugal multiplicity and child development in Jamaica. Presented at Society for Applied Anthropology; March 1992; Memphis Tennessee 22. Lester BM, Als H, Brazelton TB. Regional obstetrics anesthesia and newborn behaviors: a reanalysis toward synergistic effects. Child Dev. 1982;52:71-82 23. Hayes J, Dreher M, Nugent K. Neonatal outcomes with maternal marijuana use in Jamaican women. Pediatr Nurs. 1988;14:107-110 24. Zuckerman B, Bresnahan K. Developmental and behavioral consequences of prenatal drug and alcohol exposure. Pediatr Clin North Am. 1991;38:1387-1406 25. Lester BM. A biosocial model of infant crying. In: Lipsett L, ed. Advances in Infancy Research. New York: Ablex;1984 26. Carter W. Cannabis in Costa Rica. Philadelphia; ISHI; 1980 [End] [Additional research on marijuana and reproductive health is discussed in Exposing Marijuana Myths: A Review of the Scientific Evidence (particularly "Claim #7: Marijuana Use During Pregnancy Harms The Fetus"), by Lynn Zimmer, Ph.D., Associate Professor of Sociology, Queens College; and Dr. John P. Morgan, Professor of Pharmacology, City University of New York Medical School. See also the Portland NORML news release of March 7, 1996.]
  5. CANNABUZZOCT 11, 2017 The Golden State Goes Green California Makes Adult-Use Weed Legal on January 1. What’s Coming? by Josh Jardine PHOTOS BY JAN FRIES / EYEEM AND YANGYIN / GETTY IMAGES. COLLAGE BY MERCURY STAFF If you ask someone in Oregon what they think about people from California, and they’ll probably say, “I want them to stop moving here, driving up real estate prices, and clogging my commute.” Actually, it’s more likely the person will mumble something about how much it rains here, which means that the person is from CaliforniaAsk someone what they think about California cannabis, and you may get a blank look. Oregon is pretty much drowning in top-shelf flower, to the extent that some estimates believe we’re exporting to other states three to five times what we consume here. So we don’t really think all that much about what’s going on down south. But it may behoove Oregon to start looking at what California has planned for their recreational cannabis program rollout under Proposition 64. Oregon has had an adult-use cannabis program in effect since July 1, 2015. On January 1, 2018, California begins theirs. California already has a booming medical marijuana program, which was established in 1996 and is the oldest medical program in the country. It came about in large part as a response to the AIDS crisis, when cannabis was one of the few products—pharmaceutical or otherwise—to offer relief to those suffering the syndrome’s effects. Prior to that, the general consensus was that the best weed in North America came from the famed Emerald Triangle in Northern California, comprising Humboldt, Mendocino, and Trinity Counties. (Cue uproar from Oregon cannabis growers.) And California’s booming medical cannabis program is pretty much a sonic boom. Marijuana Business Daily reported a year ago that they estimated California had 2,756 dispensaries with a combined revenue of $844.4 million between April 2015 and March 2016. More recently, Arcview Group issued a report stating that “California accounted for 27 percent of the 2016 legal cannabis market in North America,” with Colorado accounting for 20 percent, and Washington at 11 percent. (Data for Oregon was not provided.) California’s marketplace is certainly larger. As of 2017, Oregon has a population of 4.046 million people, and a gross domestic product (GDP) of $207 billion dollars, which places it as the 24th largest state economy in the US. As of 2016, California had a population of 39.5 million and a GDP of $2.46 trillion, making its economy the sixth largest economy in the world. Obviously, more people with more money equals more cannabis sales. But is it safe? In February of this year, KNBC in Los Angeles did an investigation in which they purchased 44 samples of marijuana products—flower and vape cartridges—from 15 dispensaries in Los Angeles, Orange, Riverside, and San Bernardino counties. The results concluded, “Steep Hill Labs found 41 out of 44 samples, 93 percent, tested positive for pesticides, at levels high enough that those products would’ve been banned for sale in some other states that currently regulate the use of pesticides in marijuana products.” One vape cartridge company had 355 times the amount of myclobutanil, a fungicide, than would be allowed in some other states with cannabis testing and pesticide limits. This isn’t a wholesale indictment of the cannabis produced in California by any means, as I have tried some next-level organic offerings that were stunning in taste, appearance, and effects. And there are many excellent cannabis companies doing extraordinary work in the Golden State—I’ve been privy to some as-yet-unreleased cannabis products that were designed in California, and the innovation they demonstrate is quite impressive. Some great things are in the pipeline. I’m about to take a trip to both Northern and Southern California this week. I’m scheduled to check out some cannabis events and talk with industry players about what they see for 2018. I may even get to check out a cannabis speakeasy, where, much to the shock of Oregon lawmakers, people are gathering in a structure with walls and roof in order to consume cannabis, and there seem to be no horrendous results for the attendees or the surrounding community. Stay tuned as I journey south. If You Want To Follow Josh Please Go To This URL Below: http://www.portlandmercury.com/cannabuzz/2017/10/11/19381558/the-golden-state-goes-green
  6. CANNABUZZAUG 30, 2017 Cannabis Cookies You Should Try She Don’t Know and Elbe’s Edibles Are Making Great Stuff by Josh Jardine ELBE’S Do you like cookies? “Well,” you answer coyly, “I’m trying to be ‘good’ this month and avoid gluten, and plus, I restarted my vegan diet yet again, but I love butter so much, oh I’m so bad tee hee....” Well, golly, that’s swell and all, and, you know, gluten-free kudos to you. But since you didn’t answer my question, I will do so for you: Yes, you do like cookies. And don’t lie to me, because you are better than that, and no one likes a liar, what with their flaming trousers and all. Me? I love cookies. I care fuck-all if it has butter, sugar, wheat, or freeze-dried kittens in it. (Cannabis Kitten Cookies are not actually a thing to the best of my knowledge. Yet.) There’s a reason I am known as “Cookie Monster” in some circles. Or, simply, “That Monster.” Let’s look at two Portland companies that are making terrific cannabis-infused cookies or cookie-like treats. Both come... highly recommended. I know! Ha! Good for me. SHE DON'T KNOW SHE DON’T KNOW sdksnacks.com About that name: She Don’t Know owner and CEO Jill Trinchero says, “It seems like everyone has the answers, but who really knows?” Trinchero started SDK in 2015, foregoing gluten, preservatives, corn syrup, or dyes, and infusing her offerings with “the clear,” a super-clean THC distillate made using ethanol. Their products are micro-dosed at 5 milligrams of THC per cookie, which Trinchero says is an amount most anyone can handle. They’re made that way because, as she puts it, “Who eats half a cookie? People don’t eat half a cookie.” She readily admits to being a cannabis edible lightweight, and wanted to offer an option to others who may share her tolerance and dietary choices. SDK cookies are manufactured in a dedicated gluten-free kitchen with vegan options, but wait, come back, because they are really good, and that comes without a qualifier. I could eat these by the handful, which I haven’t done because I’m not a stoned bear with poor impulse control. Doing the Whole30, paleo, or Eat-Clean diet plan? First, don’t tell me about it, because I don’t care—no one does or ever will—then grab your dietary pious self a Tokeless B. Coconut, a raw, gluten-free, vegan, no-sugar-added bite of goodness made with organic dates, almonds, coconut, and sour cherries. The Chocolate Chip Cannabis Cookie is also gluten-free, and just as tasty. This month SDK added a savory offering with C’est La Herb, a gluten-free crisp, buttery cracker with Herbes De Provence and Maldon flake sea salt. ELBE’S EDIBLES elbesedibles.com Let’s start with the slogan on their T-shirt: “My balls. Your mouth.” No, it’s not “What Are ‘Things Trump Has Said to Women,’ Alex?” and I’m sorry that your mind went directly there. The balls in question are 15-milligram, THC-infused cake balls in numerous flavors, one of two product lines made by Elbe’s. They also make variously flavored snickerdoodle cookies, each containing 25 milligrams of THC—one is a lemon version, and on their website, they delve into why: “Lemon contains a terpene called Limone which is a hydrocarbon that has the ability to cross the blood brain barrier and interact with the brain.” They also go a bit into the differences between Delta-9 and Delta-11 THC, so you can get informed while you get high. The more you know.... Elbe’s started toiling in the cookie mines back in 2010, using a whole-cannabis-bud butter infusion. They are one of the few companies I have found in the recreational cannabis market still using full butter, which is the way I came up enjoying my edibles. All the love to my vegan friends, but there are times I want canna-infused butter. This is one of those times. The taste of Elbe’s Orange Creamsicle Cake Balls bears an uncanny resemblance to its namesake frozen treat, and they’re all too tempting to have on hand in any great quantity. A clever cutting-and-portioning guide is included in each package to help you determine your proper dose, making them easy to share. They recently dropped a Gingersnap Snickerdoodle with a one-to-one ratio of CBD and THC, containing 25 milligrams of each. After gobbling one, the result was a balanced, mellow high, with the THC nicely complemented by the CBD. URL If You're Interested In Any Of These Cannabis Stories Below: http://www.portlandmercury.com/cannabuzz/2017/08/30/19281759/cannabis-cookies-you-should-try These Are The Stories You May Be Interested In: Pardon Me If These Links Don't Work To The Stories. Then Just Use The Above URL Thanks Very Much... Peace. Sincerely, BW The Golden State Goes Green California Makes Adult-Use Weed Legal on January 1. What’s Coming? by Josh Jardine Elvy Musikka, Living Cannabis Legend The OG Cannabis Activist Gets Her Weed from Uncle Sam by Josh Jardine Quick Hits: Cool Cannabis Products New Weed Toys to Check Out by Josh Jardine
  7. Poppin Jane's Eugene Oregon ~

    Oh You're Pull'in My Leg. I Didn't Mean For You To Go To FB And You're SO Correct ! I Wish I Would Have Never Ever Let My Kids Talk Me Into FB. No Dear I Was Only Saying If Anyone Hits Either Link It Takes You Straight To FB. "I Don't Do FB" LOL ! I Like How You Said That And Believe Me I Wish And Soon I Won't Be On FB. Oh Yeah I Just Remembered... I Did Get Off Of It Once. Like Most Social Media It Can Be Pretty Addictive. Sorry For Any Confusion I May Have Brought You. Thanks Very Much For All You Do Sister Purple. Peace... Sincerely, BW

    Do You Remember When You And The Stoned Ranger Came To Portland And I Found You The Cheapest Concentrates ? In Fact You Both Came Down Twice. I Do Hope And Pray You're Doing Much Better. Sure Wish You Both Could Stay In The PNW. I Know We Once Had A Falling Out-I Kind Sir Was Out Of Line Quite Frankly And I Can't Apologize Enough. My Life As You Know Was Bad Back Then. You Must Know I've Been A Very Changed Man Every Since We Parted Ways. Just When My Wife And Your Wife Were Beginning To Become The Best Of Friends I Went And Screwed Things Up With My Mouth. Please Take Great Care Of Yourself. You've Been A Rock In My Life And You're One Special Man I Still Call My Brother. I Deeply Apologize And I Can Swear It'll Never Happen Again. I Fully Understand If You're Not Ever Willing To Give Me A 2nd Chance. You've Been Missed And I'm Happy You're Here Doing Your Thing And Helping So Many Others. I Pray You Get Your Hands Back-I Learned Tons Of Things From You Including Your Art. Peace Be With You And Lady M. Most Sincerely Grateful To Have Met You. Most Sincerely, Will
  9. Poppin Jane's Eugene Oregon ~

    EK/Or Purple Power... I Just Noticed The Links Above Send You Straight To FB And There Is Nothing About Jane's. Thanks Very Much {Picky Me I Look For These Things} Peace... Sincerely, BW
  10. Medical Dispensaries in 2017

    Ironhorse_D Thank You Very Much For These Great Posts ! Very Nice To Meet You/Hope To See You Here Sometime. Peace... Sincerely, Brother Will
  11. I Shall Return And Thank You Both Very Much. Geez Here's Another Cool Dear Sister I've Missed A Lot ! I Wonder Where She Is Now ? Dear Loverlyone Sure Did Her Research And Refused To Just Lay Back. As I Recall She Helped Her Close Family Along With Others And Was On Top Of Informing So Many In The Time That I Knew Her. She Reminds Me Of Someone Here Or Is That The Other Way Around ? Both Really Most Excellent Caregivers And Authors Of A Variety Of Topics Well Learned And Freely Given Away To Everyone Who Needs Their Information.Really Friends To Admire ! Sincerely Grateful, Brother Will
  12. Ooops, Thank You Mednurse Very Much ! Does Anyone Know Where Our Mednurse Is These Days ? {PM's Are Welcome} I Feel Like I've Been Gone For Years---> LOL ! Well Oh Silly Me ! I HAVE Been Gone For Years Upon Years HaHa ! I Sure Hope Mednurse Is Doing Fine ? She Was Such An Asset. Sister Purple You Must Have Been Here... Yes, Of Course. Other Friends/Members Too...Some Whom Are Still Here. Thank You For Any Input. Peace/Great Health/Happiness And Love... Sincerely, Brother Will
  13. Wooow ! I Really Enjoyed This...