Marijuana is touted for its medical uses, lessening pain, nausea, and other uncomfortable side effects of conditions like glaucoma, nerve pain, and cancer. Now researchers say, a chemical found in the hotly debated drug could slow or altogether stop the progression of Alzheimer's disease.
Findings of a preclinical study published in the Journal of Alzheimer's Disease, suggest very small doses of THC, a chemical found in marijuana, slow down the production of thebeta-amyloid protein, which builds up to create plaques in the brain, an accumulation of which is a known hallmark of Alzheimer's disease.
"THC is known to be a potent antioxidant,................
Marijuana compound may offer treatment for Alzheimer's disease, study suggests
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer's disease, a recent study from neuroscientists at the University of South Florida shows.
Findings from the experiments, using a cellular model of Alzheimer's disease, were reported online in the Journal of Alzheimer's Disease.
Researchers from the USF Health Byrd Alzheimer's Institute showed that extremely low doses of THC reduce the production of amyloid beta, found in a soluble form in most aging brains, and prevent abnormal accumulation of this protein -- a process considered one of the pathological hallmarks evident early in the memory-robbing disease. These low concentrations of THC also selectively enhanced mitochondrial function, which is needed to help supply energy, transmit signals, and maintain a healthy brain.
"THC is known to be a potent antioxidant with neuroprotective properties, but this is the first report that the compound directly affects Alzheimer's pathology by decreasing amyloid beta levels,
inhibiting its aggregation, and enhancing mitochondrial function," said study lead author Chuanhai Cao, PhD and a neuroscientist at the Byrd Alzheimer's Institute and the USF College of Pharmacy.
"Decreased levels of amyloid beta means........................